THE BLOOD-URINE UREA CONCENTRATION RATIO IN HYPERTENSION
نویسندگان
چکیده
منابع مشابه
Urea and creatinine concentration, the urea: creatinine ratio
This is the second of two articles that together aim to explore current understanding of the clinical value of measuring serum/plasma urea concentration. The main focus of the first article [1] was physiological topics, such as urea production and renal processing of urea. The causes of increased and reduced plasma/serum urea concentration were also discussed. The main focus of this second arti...
متن کاملEffect of urea on urine concentration in the rat.
Urea is the principal end-product of nitrogen metabolism in mammals and is excreted almost entirely through the kidney. Studies by Shannon (1, 2) in the dog and by Chasis and Smith (3, 4) in man have shown that the renal clearance of urea is less than the inulin or creatinine clearance at all rates of urine flow, and that the clearance of urea increases as the urine flow rises. These observatio...
متن کاملUrea and the clinical value of measuring blood urea concentration
Urea is the principal nitrogenous waste product of metabolism and is generated from protein breakdown. It is eliminated from the body almost exclusively by the kidneys in urine, and measurement of its concentration, first in urine and later in blood, has had clinical application in the assessment of kidney (renal) function for well over 150 years. This is the first of two articles that together...
متن کاملThe Direct Colorimetric Determination of Urea in Blood and Urine
Methods for the determination of urea in biological fluids have passed through an interesting cycle (cf. Peters and Van Slyke (3) pp. 539-544). The earliest procedures were strictly chemical ones, involving precipitation of the urea as an insoluble mercury complex or decomposition of the urea by means of heat or hypobromite. The use of the highly specific enzyme urease occurring in the jack and...
متن کاملTriazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration.
Urea transport (UT) proteins facilitate the concentration of urine by the kidney, suggesting that inhibition of these proteins could have therapeutic use as a diuretic strategy. We screened 100,000 compounds for UT-B inhibition using an optical assay based on the hypotonic lysis of acetamide-loaded mouse erythrocytes. We identified a class of triazolothienopyrimidine UT-B inhibitors; the most p...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1927
ISSN: 0021-9738
DOI: 10.1172/jci100143